A major test for dietary supplements People who received omega-3 fish oil supplements in randomized clinical trials had lower risks of heart attack and other cardiovascular disease (CVD) events than those who were given placebo, according to a new meta-analysis from Harvard T.H. Chan School of Public Health and Brigham and Women’s Hospital.Researchers found an association between daily omega-3 supplementation and reduced risk of most CVD outcomes, including heart attack, death from coronary heart disease, and death from CVD, but did not see benefit for stroke. In addition, higher doses of omega-3 fish oil supplements appeared to provide even greater risk reduction.The study was published today online in the Journal of the American Heart Association.“This meta-analysis provides the most up-to-date evidence regarding the effects of omega-3 supplementation on risk of multiple CVD outcomes. We found significant protective effects of daily omega-3 supplementation against most CVD outcome risks, and the associations appeared to be in a dose-response manner,” said first author Yang Hu, a postdoctoral research fellow in the Department of Nutrition at Harvard Chan School.While observational studies have shown an association between fish consumption and lower heart disease risk, results from randomized controlled trials have been inconsistent. Two reviews published last year did not find clear evidence for benefit.In this new analysis, the researchers did an updated meta-analysis that included three recently completed large-scale trials, which increased the sample size by 64 percent. The total population analyzed by Hu and colleagues included more than 120,000 adults in 13 randomized trials worldwide. The analysis included the VITAL trial, the largest randomized trial of omega-3s to date.The findings showed that people who took daily omega-3 fish oil supplements, compared with those who took a placebo, lowered their risk for most CVD outcomes except stroke, including an 8 percent reduced risk for heart attack and death from coronary heart disease (CHD). The association was particularly evident at higher doses of omega-3 fish oil supplementation. This finding may suggest that marine omega-3 supplementation dosage above the 840 mg/day used in most randomized clinical trials may provide greater reductions in CVD risk. Given that several million people experience these CVD events worldwide each year, even small reductions in risk can translate into hundreds of thousands of heart attacks and CVD deaths avoided, according to the researchers.“Although public health recommendations should focus on increasing fish consumption, having an overall heart-healthy diet, being physically active, and having other healthy lifestyle practices, this study suggests that omega-3 supplementation may have a role in appropriate patients,” said senior author JoAnn Manson, chief of the Division of Preventive Medicine at Brigham and Women’s Hospital and professor in the Department of Epidemiology at Harvard Chan School. Manson is also the director of the large-scale VITAL trial.Other Harvard Chan School authors included Frank Hu.VITAL was supported by grants U01 CA138962 and R01 CA138962 from the National Institutes of Health. Pharmavite LLC of Northridge, Calif., (vitamin D) and Pronova BioPharma of Norway and BASF (Omacor fish oil) donated the study agents and matching placebos. Related VITAL researcher JoAnn Manson outlines findings on vitamin D, omega-3
With Tony nominations just around the corner, audiences are catching this season’s new musicals before some celebrate a post-announcement high tide. School of Rock surpassed the million-dollar mark this past week, taking in $1,003,657. In its first full week after opening, Waitress reached full capacity at 100.08% and grossed $907,936. Shuffle Along opened officially on April 28 and ended the week with a house just shy of Standing Room Only. Meanwhile, the expected leader of the pack, Hamilton, remained in the top five by gross. Tune in on May 3 at 8:30 AM to see how these shows and more fare when the Tony Award nominations are announced!Here’s a look at who was on top—and who was not—for the week ending May 1:FRONTRUNNERS (By Gross)1. The Lion King ($1,950,539)2. Hamilton ($1,818,758)3. Wicked ($1,625,910)4. Aladdin ($1,494,979)5. The Book of Mormon ($1,332,910)UNDERDOGS (By Gross)5. Long Day’s Journey Into Night ($344,594)*4. Tuck Everlasting ($340,152)**3. The Father ($294,222)2. Eclipsed ($269,110)1. Disaster! ($264,032)FRONTRUNNERS (By Capacity)1. The Book of Mormon (102.16%)2. Hamilton (101.76%)3. Waitress (100.81%)4. The Lion King (99.99%)5. Aladdin (99.70%)UNDERDOGS (By Capacity)5. Jersey Boys (62.08%)4. Bright Star (62.07%)3. Finding Neverland (61.65%)2. Eclipsed (55.92%)1. Disaster! (50.01%)* Number based on preview performance and six regular performances** Number based on one preview performance and seven regular performancesSource: The Broadway League Alex Brightman in ‘School of Rock'(Photo: Matthew Murphy) View Comments
European governments have been tightening controls on Chinese companies building 5G networks following diplomatic pressure from Washington, which alleges Huawei equipment could be used by Beijing for spying. Huawei has repeatedly denied being a national security risk.PTS has given companies taking part in 5G spectrum auctions until January 1, 2025 to remove Huawei and ZTE equipment from their existing infrastructure and core functions.The auctions are expected to start next week, and to benefit Huawei’s Nordic rivals, Nokia and Ericsson.- Advertisement – © Thomson Reuters 2020Are iPhone 12 mini, HomePod mini the Perfect Apple Devices for India? We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts, Google Podcasts, or RSS, download the episode, or just hit the play button below. – Advertisement – Sweden last month banned Huawei and peer ZTE from its 5G network, joining other European nations that have restricted the role of Chinese suppliers on security grounds.“We think the decision that has been taken is not good for customers nor for Sweden in general,” Kenneth Fredriksen, Huawei’s Executive Vice President, Central East Europe and Nordic Region, told Reuters.“We therefore want a Swedish court to look at if the decision has been taken through a proper process and according to the law.”- Advertisement – Huawei has appealed against Sweden’s decision to exclude the Chinese telecoms equipment maker from 5G networks, the Swedish telecoms regulator PTS said on Friday.“What happens now is we will send the appeal to the administrative court of Stockholm. After that, they will handle this case,” a PTS spokesman said.- Advertisement –
The UK pensions regulator has said it used the threat of its anti-avoidance powers to secure a better deal for members of a small private sector defined benefit (DB) scheme following the sale of the sponsoring business.The Pensions Regulator (TPR) published a regulatory intervention report on the case of the sale of data management services provider Database Group, which it said would have led to “an insecure future” for the DB scheme of one of its trading companies.This is a closed pension scheme with around 100 members that, as at 31 May 2015, had an estimated buyout funding deficit of £7.7m (€8.6m).In 2015, an offer was made for Database Group on the condition that the company be sold without its DB pension scheme. This formed the basis of an application for clearance submitted to TPR in July 2015.Nicola Parish, executive director for front-line regulation at TPR, said being approached for clearance allowed TPR “to have a seat at discussions and ensure a better outcome for scheme members”.The regulator opened an avoidance investigation because it had concerns about the risk of the offer effectively removing support from the scheme, although it “understood the commercial rationale and wider benefits of the Merkle acquisition”, according to Parish.“This case demonstrates TPR will consider using anti-avoidance powers in respect of a smaller scheme where appropriate,” she said.“It illustrates how the existence of these powers can act as a deterrent against possible avoidance activity.”In other news, the UK government – via the department for business, energy and industrial strategy – has responded to a damning parliamentary report on the collapsed high street retailer BHS, whose two underfunded schemes were transferred to the PPF.In a letter to the chairmen of the committees behind the joint investigation, business minister Margot James said the government was “determined to ensure the Pensions Regulator has the powers it needs to deter and tackle misbehaviour and that these address emerging threats and challenges”.She added: “We are actively considering these issues, and, should we need to bring forward further legislation in light of all the evidence, then we will, of course, do so.”She also said the government “shares your concern” about “the sharp contrast” between the impact of BHS’s collapse on workers and pensioners and payments received by senior executives at BHS and its successor owner Retail Acquisitions, and “apparent weaknesses in the corporate governance of the companies concerned”.Responses to the BHS report from Retail Acquisitions and Taveta Investments, parent of former sponsor Arcadia Group and therefore the ultimate former parent company of BHS, were also released by the work and pensions committee, in addition to a counsel opinion.Lastly, British Airways (BA) has agreed to pay deficit contributions of at least £300m a year into one of its staff pension funds to shrink the scheme’s funding shortfall, which has grown slightly since the previous three-yearly valuation to £2.8bn, according to International Airlines Group (IAG), BA’s owner.The commitment to payments into the scheme is part of an agreement signed between BA and the trustees of the New Airways Pension Scheme regarding the latest valuation as of 31 March 2015.The technical deficit of £2.8bn is wider than the £2.7bn shortfall calculated at the March 2013 valuation.The fixed deficit contributions will be made every year until 2027, according to the deal, which IAG said gave BA the flexibility to make dividend payments.The pact also capped the level of additional contributions the airline makes, based on its cash balance at 31 March in any year, at £150m a year.