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Hydroxychloroquine ineffective against mild COVID-19, US study shows

first_img“Hydroxychloroquine did not substantially reduce symptom severity or prevalence over time in non-hospitalized persons with early COVID-19,” the researchers wrote in an article to be published in the Annals of Internal Medicine journal on Thursday.The randomized, placebo-controlled study was conducted on 491 non-hospitalized patients. Owing to test shortages in the United States, only 58% of participants were tested for the disease.Although it was not an endpoint of the study, five individuals who were given hydroxychloroquine were hospitalized or died because of COVID-19, compared with eight people given a placebo.The study “provides strong evidence that hydroxychloroquine offers no benefit in patients with mild illness,” Dr. Neil Schluger of New York Medical College said in an commentary on the study, also scheduled to be published on Thursday.Vocal support from Trump raised expectations for the decades-old drug. In March, Trump said hydroxychloroquine used in combination with the antibiotic azithromycin had “a real chance to be one of the biggest game changers in the history of medicine” with little evidence to back up that claim. He later said he took the drugs preventively after two people who worked at the White House were diagnosed with COVID-19.But several placebo-controlled studies suggest the drug is ineffective to either treat or prevent the disease.”There’s just more and more data accumulated that hydroxychloroquine, at least alone does not really have any effect,” said Dr. David Boulware, the senior investigator of the trial at the University of Minnesota. “Most sort of sensible people have started to move on and really look at other therapies.”Topics : The anti-malaria drug touted by US President Donald Trump as a COVID-19 treatment was ineffective for patients with a mild version of the disease in a study conducted by researchers at the University of Minnesota.About 24% of the patients given hydroxychloroquine in the study had persisting symptoms over a 14-day period, while roughly 30% of the group given a placebo were determined to have persistent symptoms over the same period.The difference was not statistically significant, the researchers said.last_img read more

Deer Isle-Stonington girls beat Searsport to complete unbeaten regular season

first_img Bio Mike MandellMike Mandell is the sports editor at The Ellsworth American and Mount Desert Islander. He began working for The American in August 2016. You can reach him via email at [email protected] Latest posts by Mike Mandell (see all) DEER ISLE — As the gymnasium at Deer Isle-Stonington High School slowly began to clear out, Orly Vaughn stared up at the scoreboard above her in awe.No more than a half-hour earlier, Vaughn and the rest of the Deer Isle-Stonington girls’ basketball team had delivered a major win — the team’s biggest since winning the Class D state title over three decades ago, perhaps. By beating the visiting Searsport Vikings, the Mariners had completed an undefeated regular season.Yet even after the post-game fanfare had subsided, that remarkable achievement hadn’t quite registered for Vaughn. Instead, she needed a minute to take it all in.“It doesn’t feel real,” Vaughn said. “I don’t think any of us thought this would happen.”This is placeholder textThis is placeholder textBetween a “16-0” sign being passed around the gym, the team’s record being shouted over the loudspeaker and fans cheering as loudly as they could, the sights and sounds at Deer Isle-Stonington High School said it all Monday evening. Much more than an average basketball game, this was a moment that won’t soon fade away south of the Eggemoggin Reach.Deer Isle-Stonington finished the regular season with a 16-0 record Monday night with a 39-31 victory over visiting Searsport. The win put an exclamation point on a dominant two months for the Mariners, who will enter the upcoming state tournament as Class D North’s only undefeated team.“It’s just a great accomplishment for these girls,” head coach Randy Shepard said. “They took it one game at a time and believed in each other, and it’s brought them something special.”Early in the game, the visitors tested Deer Isle-Stonington’s mettle by jumping out to a 10-2 lead with stout defense and several breakaway layups. With one of the team’s leading scorers, Katie Hutchinson, in early foul trouble, it appeared as if the Mariners’ 16-0 dreams might not come to fruition.Deer Isle-Stonington’s Brienna Limeburner drives to the basket during the second half of a high school girls’ basketball game against Searsport on Feb. 5 in Deer Isle. Limeburner scored a game-high 10 points in the Mariners’ win. ELLSWORTH AMERICAN PHOTO BY MIKE MANDELLDespite those early struggles, Deer Isle-Stonington responded by limiting Searsport to four points in the second quarter. With three baskets from Brienna Limeburner and a flurry of rebounds and blocks from Vaughn, the Mariners took a 15-14 lead into halftime.The Mariners extended their advantage to eight points in the second half before Searsport (6-11) got within four, but that was as close as the Vikings would get. Kaylee Morey and Lily Gray made key free throws down the stretch to give the home team more breathing room, and the Mariners walked off the court embracing one another as they celebrated their most important victory to date.Limeburner was the team’s top scorer with 10 points, and Hutchinson added eight. Gray and Morey scored seven apiece to add to a balanced scoring effort for the Mariners.More than anything, though, Vaughn’s defense was the biggest factor in the win. The 6-foot senior recorded 17 rebounds and four blocks in her final home game to continue the Mariners’ streak of dominant defensive play, one that has been their opponents’ undoing all season.“She’s our heart and soul,” Shepard said. “Even when the shots weren’t falling and we were looking rusty, we could rely on her to make the plays we needed from her at the other end.”The Mariners’ next game will come in about two weeks’ time and will likely pit them against Ashland or Schenck in the regional quarterfinals the Cross Insurance Center. It will be the team’s fourth straight appearance in the playoffs.Over the those first three seasons, Deer Isle-Stonington was a combined 27-27 entering tournament play. This time, an undefeated bunch will be looking to prove it belongs among Class D North’s best.“With this group of players, we’ve all been together for a long time and have a great bond,” Vaughn said. “This year, it was like the stars aligned for us. We didn’t really think would go undefeated, but here we are.”Shortly after the win, the school hung a banner commemorating the defeat in its main hallway. Attached to the outside of the glass, it’s the first item visible in a trophy case that includes the boys’ basketball team’s Gold Ball from 2007 and other state, regional and local honors from past seasons.In a solid Class D field, the Mariners will have to pass even tougher tests to add more to that trophy case. Still, no matter where the Mariners go from here, the team’s place in school lore is permanent.“We’re going to get back to work soon and try to stay fresh [for the playoffs], but this is also something we’re going to enjoy,” Vaughn said. “Seeing how excited everyone is from the team to the fans is exciting for us, and as a team, we hope we’ve made the island very proud.” Latest Postscenter_img MPA approves golf, XC, field hockey, soccer; football, volleyball moved to spring – September 10, 2020 Hospice volunteers help families navigate grief and find hope – September 12, 2020 Ellsworth runners compete in virtual Boston Marathon – September 16, 2020last_img read more